Category: Landmark Decisions
RALES trial: spironlactone for heart failure
Posted by ProfJameson in Landmark Decisions on November 10th, 2009
The Headline
Spironolactone saves lives in heart failure patients
The Facts
The Big Idea:
Spironolactone reduces mobidity and mortality among heart failure patients
Study Design:
Multicenter, double-blind, randomized, placebo-controlled trial (intention to treat)
Outcomes
Death from any cause, hospitalization for cardiac problems, and a change in…
The COMET Trial : Carvedilol vs immediate release metoprolol
Posted by ProfJameson in Landmark Decisions on October 20th, 2009
The Headline
Patients with CHF taking carvedilol have significantly less mortatility than patients taking metoprolol
The Facts
The Big Idea:
This study looked to show which beta-blocker was superior, carvedilol or metoprolol.
Study Design:
Multicenter (341 centers in 15 European countries), randomized, double blind, parallel-group
Outcomes
All…
Atorvastatin for high risk patients and normal cholesterol (ASCOT-LLA)
Posted by ProfJameson in Landmark Decisions on July 29th, 2009
The Headline
Lipitor prevents cardiovascular events in people with normal cholesterol
The Facts
The Big Idea: Major cardiovascular events can be reduced with atorvastatin in patients who are not dyslipidemic
Study Design: Multicenter, randomized, placebo-controlled trial
Outcomes Nonfatal MI and fatal CHD
Number of Patients 19342 randomized, 10,305 in…
Read The Rest...