Pioglitazone and Digoxin

Dismayed by the lost market share due to pioglitazone’s propensity to worsen heart failure, the manufacturers will be producing a new combo with digoxin called Piopump

Disclaimer: In case you … Read the rest

Valproate and Minoxidil

The alopecia effects of valproate seems to have become vexing enough to prompt a combination product with minoxidil. It will be marketed for headache prophylaxis and it will be called … Read the rest

Spironolactone plus Tamoxifen

This combination of course is using the anti-estrogen properties of tamoxifen to offset the gynecomastia caused by spironolactone. It will probably be called Noestrone (Redux is already taken)

Disclaimer: In … Read the rest

Sensitivity and Specificity

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Type One and Type Two Error

The purpose of inferential statistics is to predict differences between groups in the general population by measuring the difference in a small sample.

Examples

  • Blood pressure lowering of two drugs:
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Insulin Dosing Rules

John and Albert in Bali Albert and I had to go into the beautiful mountains of the island of Bali to research these rules. Bali is one of many islands that make up the country … Read the rest

Power Calculations

Statistical Power

OK, so John Lennon didn’t really write this , but statistical power is a very abstract concept and the ability to “imagine” really helps.

Power is the probability Read the rest

Antibiotics Simplified

It might take a bit more than a minute, but we have created a powerpoint presentation that walks through most antibiotics and helps you see how one relates to another. … Read the rest

Warfarin Maintenance Dose Adjustments

Simple guidelines

Note: these are for maintenance doses only at steady state. Do NOT use these guidelines for starting someone on warfarin.

INR Dosage Adjustment
Less Than 1.3 Give them
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Millimoles and Millequivalents

Occasionally, you still need to figure out millequivalents vs millimoles. Or you may need to calculate how much sodium in half normal saline.

Two Pharm D. students prepared a powerpoint … Read the rest