Absolute vs Relative Risk Reduction

Albert and I developed an acute interest in risk reduction at about 3500 feet.

 

Examples:
Example 1A:

  • Consider the benefit of using Coumadin for Stroke prevention in Atrial Fibrillation. Moderate risk patients on placebo have 8% risk of stroke in ONE year
  • Coumadin decreases that to 3% risk of stroke in ONE year
  • Quick !! Instinctively, what is the risk reduction? ….. 5% , right? That’s absolute risk reduction, NOT relative to anything else.
  •  

    Relative Risk Reduction is RELATIVE to the baseline 8% so… 0.05/0.08 or 5% reduction /8% baseline = .62 or 62% relative risk reduction

    Example 1B:
    OK, now consider if there was a very high baseline risk of 93%

    • Suppose Coumadin decreased the risk to 88%
    • Quick !! The absolute reduction is? …. You’re right! 5% (the same as the first example)
    • The relative risk though is different. 5 / 93 = 5.3% relative risk reduction

    So which is the most important? Absolute reduction or Relative reduction. Well, they each give you different kinds of information. I prefer the absolute risk reduction, but both are important. See also the Number Needed To Treat

4 Replies to “Absolute vs Relative Risk Reduction”

  1. It’s perfect time to mzke some plans for the longer term and it’s tine to
    be happy. I have learn this post and if I
    could I desire too suggest you some attention-grabbing things
    orr tips. Perhaps you can write subsequent artixles referring to this article.
    I wish to learn more issues apporoximately it!

  2. I do not even know how I finished up here, but I assumed this submit was once great.
    I do not understand who you are however certainly you’re ging to a famous blogger if you happen to aren’t already.
    Cheers!

  3. Hmm it seems like your blog ate my first comment (it was extremely long) so I guess I’ll just sum it
    up what I wrote and say, I’m thoroughly enjoying your blog.
    I too am an aspiring blog writer but I’m still new to everything.
    Do you have any tips and hints for novice blog writers?
    I’d certainly appreciate it.

Leave a Reply

Your email address will not be published. Required fields are marked *

What is 2 + 3 ?
Please leave these two fields as-is:
IMPORTANT! To be able to proceed, you need to solve the following simple math (so we know that you are a human) :-)